Anti-Multidrug Resistance-related Protein (MRP1) Monoclonal Antibody
| Product Name | Anti-Multidrug Resistance-related Protein (MRP1) Monoclonal Antibody |
|---|---|
| Description | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. MRP1 (also known as ABCC, GS-X, ABC29) functions as a multispecific organic anion transporter, with (oxidized) glutathione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. It also transports drugs and other hydrophobic compounds in presence of glutathione. |
| Synonyms | MRP, ABCC, GS-X, MRP1, ABC29 |
| Clonality | Monoclonal |
| Clone | MRPm6 |
| Immunogen | Bacterial fusion protein containing a 170 aa segment in the carboxy-terminal end and part of the carboxy-proximal nucleotide binding domain of MRP (aa 1294 ‰â‰ÛÏ 1531) |
| Isotype | IgG1 |
| Specificity | Mab MRPm6 reacts with an internal epitope of MRP, a 180-195 kD transmembrane transporter protein, overexpressed in various human non-P-glycoprotein MDR tumor cell lines. It does not cross react with the human MDR1 and MDR3 gene products |
| Reactivity | Human |
| Applications | FC, IHC, WB |
| Form | Hybridoma culture Supernatant |
| Storage | 2-8C |
| References | Flens, MJ. et al. (1994) Cancer Res 54: 4557-4563Cole, SPC. et al. (1992) Science 258: 1650-1654Zaman et al. Proc. Natl. Acd. Sci. USA 91: 8822-8826Flens, MJ et al. (1996) Am J Pathol 148: 1237-1247Nooter et al. (1996) Abb Oncol 7: 75-81 |
| Background | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. |
| Supplier | ARP |
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