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|Product Name||Anti-MYD88 (clone AT22F11)|
|Description||Myeloid differentiation primary response gene 88 (MYD88) is adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. This protein increases IL-8 transcription. It is involved in IL-18-mediated signaling pathway. MYD88 activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes.|
|Clone||AT22F11. Anti-human MYD88 mAb, clone AT22F11, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human MYD88 protein.|
|Immunogen||Recombinant human MYD88 (1-309aa) purified from E. coli|
|Synonyms||Myeloid differentiation primary response protein MyD88, MYD88D|
|Applications||Dot blot, ELISA, WB|
|Form||Purified, in Phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol, 0.02% Sodium Azide.|
|Storage||Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles.|
|References||Bonnert TP, et al. (January 1997). FEBS Letters 402 (1): 81€“4.Lord KA, et al. (1990). Oncogene 5 (7): 1095€“7.Arancibia SA, et al. (2007). Biological research 40 (2): 97€“112.|
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