Anti-Myogenin (Skeletal Muscle Marker), Monoclonal Antibody
| Product Name | Anti-Myogenin (Skeletal Muscle Marker), Monoclonal Antibody |
|---|---|
| Description | Myogenin is a member of the MyoD family of myogenic basic helix-loop-helix (bHLH) transcription factors that also includes MyoD, Myf-5, and MRF4 (also known as herculinor Myf-6). MyoD family members are expressed exclusively in skeletal muscle and play a key role in activating myogenesis by binding to enhancer sequences of muscle-specific genes. The regulatory domain of MyoD is approximately 70 amino acids in length and includes both a basic DNA binding motif and a bHLH dimerization motif. MyoD family members share about 80% amino acid homology in their bHLH motifs. Anti-myogenin labels the nuclei of myoblasts in developing muscle tissue, and is expressed in tumor cell nuclei of rhabdomyosarcoma and some leiomyosarcomas. Positive nuclear staining may occur in Wilmsð tumor. |
| Synonyms | bHLHc3, cb553, Class C basic helix-loop-helix protein 3, Myf-4, MYF4, MYOG, Myogenic factor 4, Myogenin myogenin factor 4 |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | SPM144 |
| Immunogen | Human myogenin recombinant protein |
| Isotype | IgG1, kappa |
| Reactivity | Feline, Human, Mouse, Porcine, Rat |
| Applications | ELISA, FC, IF, IHC, IP, WB |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Gene Id | 4656 |
| Uniprot | P15173 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Wang NP et. al. Am J Pathol 1995, 147:1799-1810 |
| Supplier | ARP |
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