| Product Name | Anti-NCAM (CD56) Monoclonal Antibody |
|---|---|
| Description | This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein has been shown to be involved in development of the nervous system, and for cells involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. Alternative splicing results in multiple transcript variants. Mab RNL-1, directed against N-CAM (Neutral Cell Adhesion Molecule), reacts with normal neutral tissues and endocrine glands, such as pancreatic islet, pituitary gland and adrenal medulla. Expression was also found in Leydig cells of the testis, in the thyroid and in smooth-muscle cells of the small intestine, colon and bladder. The antibody is a valuable marker for the characterization of several neuroendocrine tumors. |
| Synonyms | CD56, NCAM, MSK39 |
| Clonality | Monoclonal |
| Clone | RNL-1 |
| Immunogen | Cytoskeletal preparation of human epidermis |
| Isotype | IgG1 |
| Specificity | In immunoblotting (Western) the antibody is reactive with 3 main clusters of protein bands in the molecular weight region of 200 kD, 100 kD, and 25‰â‰ÛÏ27 kD. |
| Reactivity | Human |
| Applications | IF, IHC |
| Form | Hyberidoma culture Supernatant |
| Storage | 2-8C |
| References | Broers, JLV. Et al. (1991) Cancer 67: 619-633Boerman, OC. Et al. (1991) Int. J. Cancer 48: 457-462 |
| Background | This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein has been shown to be involved in development of the nervous system, and for cells involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. Alternative splicing results in multiple transcript variants. |
| Supplier | ARP |
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