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|Product Name||Anti-NCK1 (clone AT6B3)|
|Description||NCK1 (NCK adaptor protein 1) is a 377 amino acid protein. NCK1 belongs to the adaptor family of proteins. It is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. NCK1 is located in the cytoplasm, but shuttles between the cytoplasm and the nucleus. Overexpression of Nck1 in NIH/3T3 cells decreases DNA synthesis stimulated by EGF.|
|Applications||Dot blot, ELISA, WB|
|Clone||Anti-human NCK1 mAb, clone AT6B3, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human NCK1 protein.|
|Form||Liquid. Supplied in Phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol, 0.02% Sodium Azide.|
|Immunogen||Recombinant human NCK1 (1-377aa) purified from E. coli|
|References||Braverman. L.E. and Quilliam. L.A. (1999) J Biol Chem 274: 5542-5549 Latreille. M. and Larose. L. (2006) J Biol Chem 281: 26633-26644 Kremer. B.E., et al. (2007) Cell 130: 837-850|
|Storage||Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles.|
|Synonyms||NCK, NCKalpha, NCK adaptor protein 1 GRB4, melanoma NCK protein, MGC12668, NCK adaptor protein 2, NCK tyrosine kinase, NCKbeta, non catalytic region of tyrosine kinase, noncatalytic region of tyrosine kinase, beta, SH2/SH3 adaptor protein NCK alpha, SH2/SH3 adaptor protein NCK beta.|
|Working Dilutions||Optimal dilution should be performed by user.|
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