| Product Name | Anti-Neu-Oncogene Protein, c-Erb-B2 Monoclonal Antibody |
|---|---|
| Description | This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. The c-Erb B2 proto-oncogene codes for a membrane protein, called neu-(c-erbB2) oncoprotein which shows considerable homology with the epidermal growth factor receptor. Several studies report the amplification in carcinomas. Overexpression of c-Erb B2 in breast cancer is a bad prognostic marker. |
| Synonyms | NEU, NGL, HER2, TKR1, CD340, HER-2, MLN 19, HER-2/neu |
| Clonality | Monoclonal |
| Clone | CB11 |
| Immunogen | Synthetic peptide (internal domain of the c-erbB-2 oncoprotein) |
| Isotype | IgG1 |
| Specificity | c-ErbB2 reacts with 185 kDa protein in immunoblotting |
| Reactivity | Human |
| Applications | IHC, RIA, WB |
| Form | Hyberidoma culture Supernatant |
| Storage | 2-8C |
| References | Vijer van de M.J. et al. (1988). Oncogene 2: 175-178 Falck V.G. et al. (1989 J. Pathol. 159:107-111 |
| Background | This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. |
| Supplier | ARP |
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