Anti-Neurofilament (H+L) (Neuronal Marker), Monoclonal Antibody
| Product Name | Anti-Neurofilament (H+L) (Neuronal Marker), Monoclonal Antibody |
|---|---|
| Description | This monoclonal antibody reacts with a 200kDa and 68kDa protein, identified as heavy and light sub-units of neurofilaments (NF-H & NF-L). Neurofilaments make up the main structural elements of axons and dendrites and are found in neurons, peripheral nerves, and sympathetic ganglion cells. Neurofilaments consist of three major subunits with molecular weights of 68kDa (NF-L), 160kDa (NF-M) and 200kDa (NF-H). Anti-neurofilament stains a number of neural, neuroendocrine, and endocrine tumors. Neuromas, ganglioneuromas, gangliogliomas, ganglioneuroblastomas, and neuroblastomas stain positively for anti-neurofilament. Neurofilaments are also present in paragangliomas as well as adrenal and extra-adrenal pheochromocytomas. Carcinoids, neuroendocrine carcinomas of the skin, and oat cell carcinomas of the lung also express neurofilament. |
| Synonyms | NEFH, Neurofilament H, Neurofilament Heavy Polypeptide 200kDa, Neurofilament Triplet H Protein, NF-H, NF200. 68kDa neurofilament protein, Light molecular weight neurofilament protein, NEFL, Neurofilament light polypeptide 68kDa, Neurofilament light polypeptide, Neurofilament protein, light chain, Neurofilament subunit NF-L, Neurofilament triplet L protein, NF-L, NF68 |
| Host | Mouse |
| Clone | SPM145 |
| Immunogen | Semi-purified human neurofilaments from spinal cord |
| Isotype | IgG1 |
| Reactivity | Human, Mouse, Rat |
| Applications | FC, IHC |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Gene Id | 4744 |
| Uniprot | P12036 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References |
Ishii M et. al. Fukushima J Med Sci. 2004;50(2):65-74. Angelides, K.J., et. al. 1989. J. Cell Biol. 108: 1495-1506 |
| Supplier | ARP |
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