Anti-NGF-Receptor (p75) / CD271 (Soft Tissue Tumor Marker), Monoclonal Antibody
| Product Name | Anti-NGF-Receptor (p75) / CD271 (Soft Tissue Tumor Marker), Monoclonal Antibody |
|---|---|
| Description | It recognizes a glycoprotein of 75kDa, identified as low affinity Nerve Growth Factor (NGF) Receptor (p75NGFR) or Neurotrophin Receptor (p75NTR). Its epitope spans in aa 1-160 of extracellular domain of NGFR/NTR. NGF-receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. NGF is important for the development, differentiation, and survival of variety of neuronal and non-neuronal cells. Its action is mediated by binding two distinct receptors, the high affinity p140 and low affinity p75. |
| Synonyms | CD271, Gp80-LNGFR, Low affinity nerve growth factor receptor, Low affinity neurotrophin receptor p75NTR, Nerve growth factor receptor (NGFR), TNFR superfamily member 16, p75 ICD, p75 Neurotrophin receptor, Tumor necrosis factor receptor superfamily member 16 (TNFRSF16) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | NGFR5 |
| Immunogen | NGFR from A875 melanoma cells |
| Isotype | IgG1, kappa |
| Reactivity | Feline, Ferret, Human, Primate, Rabbit |
| Applications | FC, IF, IHC |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Gene Id | 4804 |
| Uniprot | P08138 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Marano N, et. al. Journal of Neurochemistry, 1987, 48:225-32 |
| Supplier | ARP |
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