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|Product Name||Anti-NMNAT1 (AT4A2)|
|Description||Nicotinamide mononucleotide adenylyltransferase 1 is an enzyme that in humans is encoded by the NMNAT1 gene. It is an essential enzyme because it catalyzes the final step of NAD+ biosynthesis. There are three isoforms in humans that exhibit tissue- and organelle-specific expression. NMNAT-1 is localized exclusively in the nucleus, whereas NMNAT-2 and NMNAT-3 are found in the Golgi and mitochondria, respectively. NMNAT1 constitute a nuclear NAD+ salvage pathway which regulates the functions of NAD+-dependent enzymes such as the protein deacetylase SIRT1. NMNAT1 protects neurons from neuronal activity induced degeneration.|
|Applications||Dot blot, ELISA, WB|
|Clone||AT4A2. Anti-human NMNAT1 mAb, clone AT4A2, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human NMNAT1 protein.|
|Form||Purified, in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide|
|Immunogen||Recombinant human NMNAT1 (1-279aa) purified from E. coli|
|References||Tong Zhang, et al. (2009) J Biol Chem, 284(30): 20408-17. Felicitas Berger, et al. (2007) Proc Natl Acad Sci U S A, 104(10): 3765-3770. Schweiger M, et al. (2001) FEBS Lett, 492(1-2): 95-100|
|Storage||Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles.|
|Synonyms||NMNAT, PNAT1, Nicotinamide nucleotide adenylyltransferase 1|
|Working Dilutions||Optimal dilution should be performed by user.|
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