| Product Name | Anti-NMNAT1 (AT4A2) |
|---|---|
| Description | Nicotinamide mononucleotide adenylyltransferase 1 is an enzyme that in humans is encoded by the NMNAT1 gene. It is an essential enzyme because it catalyzes the final step of NAD+ biosynthesis. There are three isoforms in humans that exhibit tissue- and organelle-specific expression. NMNAT-1 is localized exclusively in the nucleus, whereas NMNAT-2 and NMNAT-3 are found in the Golgi and mitochondria, respectively. NMNAT1 constitute a nuclear NAD+ salvage pathway which regulates the functions of NAD+-dependent enzymes such as the protein deacetylase SIRT1. NMNAT1 protects neurons from neuronal activity induced degeneration. |
| Synonyms | NMNAT, PNAT1, Nicotinamide nucleotide adenylyltransferase 1 |
| Host | Mouse |
| Clone | AT4A2. Anti-human NMNAT1 mAb, clone AT4A2, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human NMNAT1 protein. |
| Immunogen | Recombinant human NMNAT1 (1-279aa) purified from E. coli |
| Isotype | K,IgG2b |
| Reactivity | Human, Mouse |
| Applications | ELISA, WB, Dot Blot |
| Form | Purified, in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide |
| Storage | Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles. |
| References | Tong Zhang, et al. (2009) J Biol Chem, 284(30): 20408-17. Felicitas Berger, et al. (2007) Proc Natl Acad Sci U S A, 104(10): 3765-3770. Schweiger M, et al. (2001) FEBS Lett, 492(1-2): 95-100 |
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