| Product Name | Anti-NPRAP/Neurojungin (delta-Catenin) Polyclonal Antibody |
|---|---|
| Description | This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome. |
| Synonyms | GT24, NPRAP |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide J7 (corresponding to aa 1175-1192), conjugated to KLH |
| Specificity | The antibody reacts specifically with neurojungin (deltaåÂcatenin, a unique 160 kD polypeptide of the plakoglobin / armadillo protein family) present in adhering type junctions in the nervous system, primarily expressed in the brain. DeltaåÂcatenin also binds to presenilin-1, mutations of this protein are described to play a role in familial Alzheimer's disease. No cross-reaction with other members of the armadillo / plakoglobin protein family. |
| Reactivity | Bovine, Human, Rat |
| Applications | IHC |
| Form | Stabilized Serum |
| Storage | 2-8C |
| References | Paffenholz R. et al. (1999) Exp Cell Res 250: 452-464Hatzfeld M. (2005) Eur J Cell Biol 84: 205-214Kosik KS. et al. (2005) Trends Cell Biol 15: 172-178 |
| Background | This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome. |
| Supplier | ARP |
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