| Product Name | Anti-NQO2 (AT1E3) |
|---|---|
| Description | Quinone oxidoreductase (NQO1 and NQO2) are cytosolic proteins that catalyze metabolic redaction of quinines and derivates.NQO2 is inhibited by flavones such as quercetin. Also benzo(a)pyrene is another known inhibitor of NQO2. Even though overlapping substrates specificities have been observed for NQO1 and NQO2, such as for CB1954 activation, significant differences exist in relative affinities for the various substrates.The detoxification role of NQO2 has not been found, and it has no known endogenous biological substrates. However, NQO1 plays an important role in the detoxification of various endogenous and exogenous quinones, including estrogen quinines. Also NQO2 has a melatonin-binding site, which may explain the anti-oxidant role of melatonin related with circadian rhythm. |
| Synonyms | DHQV, DIA6, QR2, Ribosyldihydronicotinamide dehydrogenase Ox2, EC 1.10.99.2, MGC94180, NAD(P)H dehydrogenase quinone 2, NAD(P)H menadione oxidoreductase 1 dioxin inducible 2, NAD(P)H menadione oxidoreductase 2 dioxin inducible, NMOR2, NQO 2, NRH dehydrogenase, NRH:quinone oxidoreductase 2, OTTHUMP00000015948, OTTHUMP00000015949, OTTHUMP00000015953, Ox 2, QR2, Quinone, Quinone reductase 2, Ribosyldihydronicotinamide dehydrogenase. |
| Host | Mouse |
| Clone | AT1E3. Anti-human NQO2 mAb, clone AT1E3, is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human NQO2 protein. |
| Immunogen | Recombinant human NQO2 (1-231aa) purified from E. coli |
| Isotype | IgG1,K |
| Reactivity | Human, Mouse |
| Applications | ELISA, WB, Dot Blot |
| Form | Purified, in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide |
| Storage | Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles. |
| References | Wu K., et al,. (1997) Arch Biochem Biophys. 347(2):221-8. aiswal AK., et al,. (1994) J Biol Chem. 269(20):14502-8. |
| Supplier | ARP |
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