| Product Name | Anti-p34 cdc-2 Monoclonal Antibody |
|---|---|
| Description | The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. The antibody detects the three bands within the 34 kD region corresponding to the p34 protein and it's cleavage products. P34cdc-2 is activated and initiates the entry of cells into mitosis, where it acts to promote nuclear envelope breakdown. Expression of p34cdc-2 reflects the proliferating potential of cells. Localization: cytoplasm |
| Synonyms | CDC2, CDC28A, P34CDC2 |
| Clonality | Monoclonal |
| Clone | POH-1 |
| Immunogen | Recombinant human p34 cdc-2 fusion protein |
| Isotype | IgG2a |
| Specificity | The antibody detects the three bands within the 34 kD region corresponding to the p34 protein and it's cleavage products. P34cdc-2 is activated and initiates the entry of cells into mitosis, where it acts to promote nuclear envelope breakdown. |
| Reactivity | Human |
| Applications | IHC, WB |
| Form | Hybridoma culture Supernatant |
| Storage | 2-8C |
| References | Lucas, J. et al.(1992) Eur. J. Biochem 207: 169-176 |
| Background | The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Supplier | ARP |
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