| Product Name | Anti-p53 Monoclonal Antibody |
|---|---|
| Description | This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). Mouse Monoclonal Antibody to p53. Excellent marker for wild-type and mutant forms of human p53 antigen. Epitope recognized by Bp53.11: 20SDLWKLLPENNV31. |
| Synonyms | P53, BCC7, LFS1, TRP53 |
| Clonality | Monoclonal |
| Clone | Bp53-11 |
| Immunogen | Recombinant human p53 (transcription domain within the NH2 terminus) |
| Isotype | IgG2a |
| Specificity | The antibody stains positively approx. 60 % of investigated carcinoma of lung, breast, colon, stomach, esophagus, pancreas, urinary bladder and testis, head and neck tumors; T-cell leukaemia, non-Hodgkin-Lymphoma, melanoma, sarcoma. |
| Reactivity | Human |
| Applications | WB |
| Form | Hybridoma culture supernatant |
| Storage | 2-8C |
| References | Bartek,J. et al. (1990). Int. J. Cancer 46: 839-844Bartek J. et al. (1993) J Pathol 169: 27-34Fisher CJ et al. (1994) Br J Cancer 60: 26-31Petersen G et al. (1995) Mol Gen Genet 249: 425-431Zarka TA et al. (2003) Int J Gynecol Cancer 13: 240-243 |
| Background | This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). |
| Supplier | ARP |
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