| Product Name | Anti-Perilipin, C-terminal specific Polyclonal Antibody |
|---|---|
| Description | Perilipin, also known as lipid droplet-associated protein or PLIN, is a protein that, in humans, is encoded by the PLIN gene. Perilipin is a protein that coats lipid droplets in adipocytes, the fat-storing cells in adipose tissue. Perilipin acts as a protective coating from the body's natural lipases, such as hormone-sensitive lipase, which break triglycerides into glycerol and free fatty acids for use in metabolism, a process called lipolysis. |
| Synonyms | PERI, PLIN, FPLD4 |
| Clonality | Polyclonal |
| Immunogen | C-terminus of perilipin (hCTA/B; aa 507 - 519; cf. Greenberg et al. 1992, JBC 266, 11341-11346) |
| Specificity | The antiserum reacts specifically with perilipins located at the surface of intracellular storage lipid droplets present e.g. in the adrenal gland, adipocytes of white and brown adipose tissue and cultured cells such as 3T3-L1 adipocytes and cultured steroidogenic adrenal cortical and Leydig cells. The antiserum does not cross react with adipophilin (ADRP) or TIP47 proteins (additional membrane of the PAT-family). |
| Reactivity | Bovine, Human |
| Applications | IHC, WB |
| Form | Stabilized Serum |
| Storage | 2-8C |
| References | Heid HW et al. (1998) Cell Tissue Res 294: 309-321Ryden M et al. (2004) Biochem Biophys Res Comm 318: 168-175Forcheron F et al. (2005) Aeterioscler Thromb Vasc Biol 25: 1-7Yamaguchi T et al. (2006) Mol Cell Biochem 284: 167-173Straub BK et al. (2008) Hepatology 47: 1936-1946Straub BK et al. (2010) Modern Pathology 23: 480-492 |
| Background | Perilipin, also known as lipid droplet-associated protein or PLIN, is a protein that, in humans, is encoded by the PLIN gene. Perilipin is a protein that coats lipid droplets in adipocytes, the fat-storing cells in adipose tissue. Perilipin acts as a protective coating from the body's natural lipases, such as hormone-sensitive lipase, which break triglycerides into glycerol and free fatty acids for use in metabolism, a process called lipolysis. |
| Supplier | ARP |
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