| Product Name | Anti-Perilipin Antibody Polyclonal Antibody |
|---|---|
| Description | Perilipin, also known as lipid droplet-associated protein or PLIN, is a protein that, in humans, is encoded by the PLIN gene. Perilipin is a protein that coats lipid droplets in adipocytes, the fat-storing cells in adipose tissue. Perilipin acts as a protective coating from the body's natural lipases, such as hormone-sensitive lipase, which break triglycerides into glycerol and free fatty acids for use in metabolism, a process called lipolysis. |
| Synonyms | PERI, PLIN, FPLD4 |
| Clonality | Polyclonal |
| Immunogen | Duplicated N-terminus of perilipin (aa 1-20; cf. Greenberg et al. 1992, JBC 266, 11341-11346) |
| Specificity | Specific for human, bovine, rat, mouse perilipin. The antiserum reacts specifically with perilipins (A and B) located at the surface of intracellular storage lipid droplets present e.g. in the adrenal gland, adipocytes of white and brown adipose tissue and cultured cells such as 3T3-L1 adipocytes and cultured steroidogenic adrenal cortical and Leydig cells. It also is a useful pathological marker since perilipin becomes expressed de novo in hepatocyte steatogenesis. The antiserum does not cross-react with ADRP (adipophilin) or TIP47 proteins (additional members of the PAT-family). |
| Reactivity | Bovine, Human, Mouse, Rat |
| Applications | IHC, WB |
| Form | Stabilized Serum |
| Storage | 2-8C |
| References | Heid HW et al. (1998) Cell Tissue Res 294: 309-321 Ryden M et al. (2004) Biochem Biophys Res Comm 318: 168-175 Forcheron F et al. (2005) Aeterioscler Thromb Vasc Biol 25: 1-7 Yamaguchi T et al. (2006) Mol Cell Biochem 284: 167-173 Straub BK et al. (2008) Hepatology 47: 1936-1946 Straub BK et al. (2010) Modern Pathology 23: 480-492 |
| Background | Perilipin, also known as lipid droplet-associated protein or PLIN, is a protein that, in humans, is encoded by the PLIN gene. Perilipin is a protein that coats lipid droplets in adipocytes, the fat-storing cells in adipose tissue. Perilipin acts as a protective coating from the body's natural lipases, such as hormone-sensitive lipase, which break triglycerides into glycerol and free fatty acids for use in metabolism, a process called lipolysis. |
| Supplier | ARP |
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