| Product Name | Anti-Periplakin Polyclonal Antibody |
|---|---|
| Description | The protein encoded by PPL gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling. |
| Synonyms | PPL |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptides of human periplakin (P1a/b, P2a/b, P3a/b), coupled to KLH |
| Specificity | Specific for periplakin, a 190 kD protein localized e.g. in epidermis (cornified envelope) and cortical lens fiber cells |
| Reactivity | Bovine, Human |
| Applications | IF, IP, WB |
| Form | Stabilized Serum |
| Storage | 2-8C |
| References | Straub BK. et al. (2003) Eur J Cell Sci 116: 4985-4995 |
| Background | The protein encoded by PPL gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling. |
| Supplier | ARP |
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