| Product Name | Anti-Phakinin Polyclonal Antibody |
|---|---|
| Description | More than 99% of the vertebrate ocular lens is comprised of terminally differentiated lens fiber cells. Two lens-specific intermediate filament-like proteins, the protein product of this BFSP2 gene (phakinin), and filensin, are expressed only after fiber cell differentiation has begun. Both proteins are found in a structurally unique cytoskeletal element that is referred to as the beaded filament (BF). Mutations in this gene have been associated with juvenile-onset, progressive cataracts and Dowling-Meara epidermolysis bullosa simplex. |
| Synonyms | BFSP2, CP47, CP49, LIFL-L, CTRCT12, PHAKOSIN |
| Clonality | Polyclonal |
| Immunogen | Phakinin purified from calf lens |
| Specificity | Specific detection of phakinin (Mr 47,000 polypeptide), intermediate filament protein detected in lens. Specific note: the antiserum cross react with filensin (115kD polypeptide also present in lens). |
| Reactivity | Bovine, Human |
| Applications | IHC, WB |
| Form | Stabilized Serum |
| Storage | 2-8C |
| References | Merdes, A. et al. (1993) J. Cell Biol. 123: 1507-1516Gounari, F. et al. (1993) J. Cell Biol. 121: 847-853 |
| Background | More than 99% of the vertebrate ocular lens is comprised of terminally differentiated lens fiber cells. Two lens-specific intermediate filament-like proteins, the protein product of this BFSP2 gene (phakinin), and filensin, are expressed only after fiber cell differentiation has begun. Both proteins are found in a structurally unique cytoskeletal element that is referred to as the beaded filament (BF). Mutations in this gene have been associated with juvenile-onset, progressive cataracts and Dowling-Meara epidermolysis bullosa simplex. |
| Supplier | ARP |
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