| Product Name | Anti-PIK3CG Polyclonal Antibody |
|---|---|
| Description | Phosphoinositide 3-kinase (PI3K) catalyzes the production of phosphatidylinositol-3,4,5-triphosphate by phosphorylating phosphatidylinositol (PI), phosphatidylinositol-4-phosphate (PIP) and phosphatidylinositol-4,5-bisphosphate (PIP2). Growth factors and hormones trigger this phosphorylation event, which in turn coordinates cell growth, cell cycle entry, cell migration, and cell survival. PTEN reverses this process, and the PI3K signaling pathway is constitutively activated in human cancers that have loss of function of PTEN. PI3Ks are composed of a catalytic subunit (p110) and a regulatory subunit. Various isoforms of the catalytic subunit (p110_, p110_, p110_, and p110_) have been isolated, and the regulatory subunits that associate with p110_, p110_, and p110_ are p85_ and p85_. In contrast, p110_ associates with a p101 regulatory subunit that is unrelated to p85. Furthermore, p110_ is activated by __ subunits of heterotrimeric G proteins. |
| Host | Rabbit |
| Immunogen | Recombinant protein of human PIK3CG |
| Isotype | IgG |
| Reactivity | Human |
| Applications | ELISA, WB |
| Form | Liquid, in PBS with 0.02% sodium azide, 50% glycerol, pH 7.3. |
| Storage | Store at -20C or -80C. Avoid repeated freeze/thaw cycles. |
| Background | Phosphoinositide 3-kinase (PI3K) catalyzes the production of phosphatidylinositol-3,4,5-triphosphate by phosphorylating phosphatidylinositol (PI), phosphatidylinositol-4-phosphate (PIP) and phosphatidylinositol-4,5-bisphosphate (PIP2). Growth factors and hormones trigger this phosphorylation event, which in turn coordinates cell growth, cell cycle entry, cell migration, and cell survival. PTEN reverses this process, and the PI3K signaling pathway is constitutively activated in human cancers that have loss of function of PTEN. PI3Ks are composed of a catalytic subunit (p110) and a regulatory subunit. Various isoforms of the catalytic subunit (p110_, p110_, p110_, and p110_) have been isolated, and the regulatory subunits that associate with p110_, p110_, and p110_ are p85_ and p85_. In contrast, p110_ associates with a p101 regulatory subunit that is unrelated to p85. Furthermore, p110_ is activated by __ subunits of heterotrimeric G proteins. |
| Supplier | Cusabio |
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