Anti-PKLR (clone AT1E3)

Antibodies, Monoclonal Antibodies
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Product Name Anti-PKLR (clone AT1E3)
Description PKLR is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. The PKLR gene encodes the L- and R-type isoenzymes through alternative splicing events under the control of different promoters. The L-type isoform also exists as a tetramer and is upregulated by glucose with implications in maturity-onset diabetes of the young.
Reactivity Human
Applications Dot blot, ELISA, WB
Clone AT1E3. Anti-human PKLR mAb, clone AT1E3, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human PKLR protein.
Concentration 0.1 mg/ml
Form Purified, in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide
Species Mouse
Host Mouse
Isotype IgG1, K
Immunogen Recombinant human PKLR (47-574aa) purified from E. coli
Interest Fields Signal Transduction
NCBI Number NP_000289
References Meza NW., et al. (2009). Mol Ther. 17(12):2000-9. Roy MF., et al. (2007). J Exp Med. 204(12):2949-61.
Storage Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles.
Synonyms Pyruvate kinase isozymes R/L, PK1, PKL, PKR, PKRL, RPK
Working Dilutions Optimal dilution should be performed by user.

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