| Product Name | Anti-Plakoglobin/ g-Catenin Monoclonal Antibody |
|---|---|
| Description | This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. PG 5.1 represents an excellent marker for all forms of intercellular adhering junctions, such as: desmosomes of epithelial and myocardial cells (incl. cultured cells); zonulae and fasciae adherentes of epithelia, endothelia of blood vessels and myocardial cells; adherens-type junctions (e.g. lens tissue, pigmented retinal cells, Sertoli cells of testis). The PG 5.1 epitope maps within the C-terminus at the extreme end of repeat 13 (aa 632-687) of plakoglobin. Polypeptide reacting: Mr 83 000 Plakoglobin, band 5 polypeptide of intercellular adhering junctions (identical to gamma-catenin) |
| Synonyms | DP3, PDGB, PKGB, CTNNG, DPIII, ARVD12 |
| Clonality | Monoclonal |
| Clone | PG 5.1 |
| Immunogen | Plakoglobin, band 5 protein from bovine snout epidermis |
| Isotype | IgG2b |
| Specificity | Reactivities on cultured cell line: Cell cultures forming monolayers |
| Reactivity | Gallus, Bovine, Human, Mouse, Rat, Zebrafish |
| Applications | IF, IHC, IP, WB |
| Form | Purified (Protein A), in PBS containing 1% BSA and 0.1% sodium-azide |
| Storage | 2-8C for immediate use, or at -2°C (aliquot) |
| References | Boehnke, K et al. (2007) Eur J Cell Biol 86: 731-746Pieperhoff S et al. (2007) Eur J Cell Biol 86: 377-391Kartenbeck, J. et al. (2005) Eur J Cell Biol 84: 417-430Caldelari, R et al. (2001) J Cell Biol 153: 823-834Cowin, P. et al. (1986) Cell 46: 1063-1073 |
| Background | This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. |
| Supplier | ARP |
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