Anti-Plakophilin 2 (2a+2b)-Multi-epitope cocktail Monoclonal Antibody
| Product Name | Anti-Plakophilin 2 (2a+2b)-Multi-epitope cocktail Monoclonal Antibody |
|---|---|
| Description | This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene product may regulate the signaling activity of beta-catenin. Two alternately spliced transcripts encoding two protein isoforms have been identified. A processed pseudogene with high similarity to this locus has been mapped to chromosome 12p13. Mouse Monoclonal Antibody to Plakophilin 2 (2a+2b)-Multi-epitope cocktail. Plakophilin 2 assembles with other proteins to form the desmosomal plaque in simple and glandular epithelia, the basal layer of certain stratified epithelia, all layers of some stratified epithelia, and in nonepithelial desmosome-possessing tissues such as myocardium, Purkinje fibers, and dendritic reticulum of lymph node follicles. In all these cells, including a variety of cell types devoid of desmosomes, plakophilin 2 is highly enriched in the karyoplasm. Polypeptide reacting: Plakophilin 2, Mr 100 kD (SDS-PAGE); MW calculated from aa sequence: 92,750 (pI 9.33) and 97,410 (pI 9.38). |
| Synonyms | ARVD9, PKP2 |
| Clone | PP2/62; PP2/86; PP2/150 |
| Immunogen | Synthetic carboxyterminal peptide (24 aa) of human plakophilin 2 |
| Isotype | All IgG1 |
| Specificity | The mabs react with plakophilin 2, a member of the arm-repeat family of proteins which can occur in at least 2 splice forms (2a and 2b). Positive staining was obtained with several carcinomas derived from simple-type epithelia (e.g. hepatomas, colon carcinomas) and some adenocarcinomas derived from stratified epithelia (oesophagus carcinoma). The antibody was negative with all leiomyosarcomas tested. |
| Reactivity | Amphibian, Bovine, Canine, Human |
| Applications | IHC, WB |
| Form | Hybridoma culture supernatant |
| Storage | 2-8C |
| References | Mertens, C..et al. (1996) J. Cell Biol 135: 1009-1025Mertens, C. et al. (1999) Differentiation 64: 277-290Akat K et al. (2003) Acta Neuropathol 106: 337-347Goossens S et al. (2007) J Cell Sci 120: 2126-2136Pieperhoff S et al. (2007) Eur J Cell Biol 86: 377-391 |
| Supplier | ARP |
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