| Product Name | Anti-PLCG2 Polyclonal Antibody |
|---|---|
| Description | Phosphoinositide-specific phospholipase C (PLC) plays a significant role in transmembrane signaling. In response to extracellular stimuli such as hormones, growth factors and neurotransmitters, PLC hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) to generate two secondary messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). At least four families of PLCs have been identified: PLC_, PLC_, PLC_ and PLC_. The PLC_ subfamily includes four members, PLC_1-4. All four members of the subfamily are activated by _- or _-_-subunits of the heterotrimeric G-proteins.Phosphorylation is one of the key mechanisms that regulates the activity of PLC. Phosphorylation of Ser1105 by PKA or PKC inhibits PLC_3 activity. Ser537 of PLC_3 is phosphorylated by CaMKII, and this phosphorylation may contribute to the basal activity of PLC_3. PLC_ is activated by both receptor and nonreceptor tyrosine kinases.PLC_ forms a complex with EGF and PDGF receptors, which leads to the phosphorylation of PLC_ at Tyr771, 783 and 1245. Phosphorylation by Syk at Tyr783 activates the enzymatic activity of PLC_1. |
| Host | Rabbit |
| Immunogen | Recombinant protein of human PLCG2 |
| Isotype | IgG |
| Reactivity | Human |
| Applications | ELISA, IHC, WB |
| Form | Liquid, in PBS with 0.02% sodium azide, 50% glycerol, pH 7.3. |
| Storage | Store at -20C or -80C. Avoid repeated freeze/thaw cycles. |
| Background | Phosphoinositide-specific phospholipase C (PLC) plays a significant role in transmembrane signaling. In response to extracellular stimuli such as hormones, growth factors and neurotransmitters, PLC hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) to generate two secondary messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). At least four families of PLCs have been identified: PLC_, PLC_, PLC_ and PLC_. The PLC_ subfamily includes four members, PLC_1-4. All four members of the subfamily are activated by _- or _-_-subunits of the heterotrimeric G-proteins.Phosphorylation is one of the key mechanisms that regulates the activity of PLC. Phosphorylation of Ser1105 by PKA or PKC inhibits PLC_3 activity. Ser537 of PLC_3 is phosphorylated by CaMKII, and this phosphorylation may contribute to the basal activity of PLC_3. PLC_ is activated by both receptor and nonreceptor tyrosine kinases.PLC_ forms a complex with EGF and PDGF receptors, which leads to the phosphorylation of PLC_ at Tyr771, 783 and 1245. Phosphorylation by Syk at Tyr783 activates the enzymatic activity of PLC_1. |
| Supplier | Cusabio |
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