Anti-PNL2 (Melanoma Associated Antigen), Monoclonal Antibody
| Product Name | Anti-PNL2 (Melanoma Associated Antigen), Monoclonal Antibody |
|---|---|
| Description | Anti-PNL2 is a novel monoclonal antibody, which has recently been introduced as an immunohistochemical reagent to stain melanocytes and tumors derived therefrom. The antigen recognized by PNL2 is different from Melan A and gp100. Its epitope is not destroyed by digestion with neuraminidase i.e. its epitope id not glycosylated. Anti-PNL2 may be most useful because of its high sensitivity for metastatic melanoma (87%), as opposed to 76% for anti-HMB45 and 82% for anti-MART-1. Anti-PNL2 labels intra-epidermal nevi while the dermal component of compound nevi are largely non-reactive with anti-PNL2. Antibodies against PNL2, MART-1 (Melan A) and HMB45 stain most clear cell sarcoma cells and a few cells in angio-myolipomas and lymphangioleiomyomatosis. Anti-PNL2 is a useful antibody for the identification of melanomas and clear cell sarcomas. Differential diagnosis is aided by the results from a panel of antibodies, including antibodies against HMB45, MART-1, tyrosinase, and MiTF. |
| Synonyms | Human Melanoma Associated Antigen, PNL2 |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | PNL2 |
| Immunogen | Melanocyte antigen |
| Isotype | IgG1 |
| Reactivity | Canine, Human, Mouse |
| Applications | IF, IHC |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Rochaix, P et al. PNL2, a New Monoclonal Antibody Directed against a Fixative-Resistant Melanocyte Antigen. Mod Pathol 2003;16(5):481-490.J. A. Ramos-Vara and M. A. Miller. Immunohistochemical Identification of Canine Melanocytic Neoplasms With Antibodies to Melanocytic Antigen PNL2 and Tyrosinase: Comparison With Melan A. Veterinary Pathology OnlineFirst, published on September 21, 2010 as doi:10.1177/0300985810382095 |
| Supplier | ARP |
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