| Product Name | Anti-PNPO (clone AT2C7) |
|---|---|
| Description | PNPO (pyridoxamine 5'-phosphate oxidase) is a 261 amino acid protein belonging to the pyridoxamine 5'-phosphate oxidase family. It is the rate-limiting enzyme in vitamin B6 synthesis. Vitamin B6 (Pyridoxal 5-prime-phosphate or PLP) is vital for normal cellular function, and some cancer cells have notable differences in vitamin B6 metabolism compared to their normal counterparts. Vitamin B6 is a required co-factor for enzymes involved in both homocysteine metabolism and synthesis of neurotransmitters such as catecholamine. |
| Synonyms | Pyridoxine-5'-phosphate oxidase, FLJ10535, PDXPO |
| Host | Mouse |
| Clone | AT2C7. Anti-human PNPO mAb, clone AT2C7, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human PNPO protein. |
| Immunogen | Recombinant human PNPO (57-261aa) purified from E. coli |
| Isotype | IgG1,K |
| Reactivity | Human, Mouse |
| Applications | ELISA, WB, Dot Blot |
| Form | Purified, in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide |
| Storage | Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles. |
| References | Ngo EO, et al. (Jun 1998). Biochemistry 37 (21): 7741-8.Mills PB, Surtees RA, et al. (2005). Hum. Mol. Genet. 14 (8): 1077-86.Kang JH, et al. (Jun 2004). Eur J Biochem 271 (12): 2452-61. |
| Supplier | ARP |
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