| Product Name | Anti-Progesterone, Monoclonal Antibody |
|---|---|
| Description | This monoclonal antibody is specific for progesterone. It exhibits minimal cross reactivity with related compounds in ELISA. It reacts with Progesterone-11a-HMS-BSA: 100%; 5-beta-Pregnane-3,20-dione: 48%; 5-alpha-Pregnane-3,20-dione: 26.4%; 17-alpha-Hydroxyprogesterone: 2.5%; 20-alpha-Hydroxyprogesterone: 0.04%. Progesterone is a steroid hormone synthesized from the cholesterol derivative, pregnenolone, in the cortex of the adrenal gland. Progesterone is secreted by the corpus luteum and acts to prepare the endometrium for the implantation of a fertilized egg. During pregnancy, it is secreted by the placenta to prevent spontaneous abortion and to stimulate the development of mammary tissue to produce milk. Thus, progesterone plays a central role in the reproductive events associated with the establishment and maintenance of pregnancy. Luteinized theca cells of normal ovary secrete progesterone. The determination of progesterone concentrations in the body fluids is of great value for endocrinological investigations in women. This monoclonal antibody may prove useful in identification of ovarian tumors. |
| Synonyms | Pregn 4 ene 3 20 dione, Pregn 4 ene 3 20 dione |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 6-5E-3F |
| Immunogen | Progesterone hemisuccinate conjugated to bovine serum albumin |
| Isotype | IgG1, kappa |
| Applications | ELISA, IHC, RIA |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Fantl, V.E., Wang, D.Y., Knyba, R.E. 1982. The production of high affinity monoclonal antibodies to Progesterone. J. Steroid Biochem. 17: 125-130 |
| Supplier | ARP |
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