| Product Name | Anti-Rac2 (clone AT2G11) |
|---|---|
| Description | Rac2(Ras-related C3 botulinum toxin substrate 2), a small (21 kDa) signaling G protein, belongs to the family of Rho GTPases regulating a variety of biological response pathways that include cell motility, cell division, gene transcription, and cell transformation. Upon GTP loading, a conformational change takes place that allows Rac2 protein to interact with several downstream effectors that ultimately process the information and propagate the signal within the cell, causing changes in the actin cytoskeleton, release of inflammatory modulators and innate immunity. |
| Synonyms | EN-7, Gx, HSPC022, Ras-related C3 botulinum toxin substrate 2, EN 7, EN7, HSPC 022, p21 Rac 2, p21 Rac2, p21Rac2, RAC 2, Ras related C3 botulinum toxin substrate 2, Ras related C3 botulinum toxin substrate 3, Rho family small GTP binding protein Rac 2, Rho family small GTP binding protein Rac2, Small G protein. |
| Host | Mouse |
| Clone | AT2G11. Anti-human RAC2 mAb, clone AT2G11, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human RAC2 protein. |
| Immunogen | Recombinant human RAC2 (1-189aa) protein purified from E. coli |
| Isotype | K,IgG2b |
| Reactivity | Human, Mouse |
| Applications | ELISA, WB, Dot Blot |
| Form | Purified, in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide |
| Storage | Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles. |
| References | Mizuno T, Kaibuchi K, Ando S, et al. (1992). J. Biol. Chem. 267 (15): 10215-8.Williams DA, Tao W, Yang F, et al. (2000). Blood 96 (5): 1646-54.Kinsella BT, Erdman RA, Maltese WA (1991). J. Biol. Chem. 266 (15): 9786-94. |
| Supplier | ARP |
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