| Product Name | Anti-S100A9 (Macrophage Marker), Monoclonal Antibody |
|---|---|
| Description | This monoclonal antibody stains the cytoplasm of macrophages and histiocytes in hematopoietic organs, Kupffer_Ûªs cells of the liver and Langerhan_Ûªs cells of the skin. It also stains the mantle zone B-lymphocytes of the lymph node and spleen, spermatogonia, and chief cells of the stomach. S100A9 is expressed by macrophages in acutely inflamed tissues and in chronic inflammation. It is detected in peripheral blood leukocytes, in neutrophils and granulocytes. It is present at sites of vascular inflammation. S100A9 is also expressed in epithelial cells constitutively or induced during dermatoses. S100A9 is a Calcium-binding protein. It has antimicrobial activity towards bacteria and fungi. It is important for resistance to invasion by pathogenic bacteria. It up-regulates transcription of genes that are under the control of NF-kappa-B. S100A9 plays a role in the development of endotoxic shock in response to bacterial lipopolysaccharide (LPS). It promotes tubulin polymerization when unphosphorylated. It also promotes phagocyte migration and infiltration of granulocytes at sites of wounding. It plays a role as a pro-inflammatory mediator in acute and chronic inflammation and up-regulates the release of IL8 and cell-surface expression of ICAM1. |
| Synonyms | S100-A9, MRP14, calgranulin-B, calprotectin L1H subunit, leukocyte L1 complex heavy chain, migration inhibitory factor-related protein 14, S100 calcium-binding protein A9 (calgranulin B)Human Gene SymbolS100A9Hu Gene Location1q21 |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 47-8D3 |
| Immunogen | Human peripheral blood monocyte components |
| Isotype | IgG1, kappa |
| Reactivity | Human, Rat |
| Applications | FC, IF, IHC |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% azide. Also available WITHOUT azide at 1.0mg/ml. |
| Gene Id | 6280 |
| Uniprot | P06702 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Flavell DJ. et al., J. Histochem. Cytochem. 35, 12171226, 1987.Facchetti F. et al., Am. J. Clin. Pathol. 92, 4250, 1989.Bardadin KA. et al., J. Pathol. 164, 253259, 1991. Goebeler M. Et al., J. Leukocyte Biol. 55, 259-261, 1994 |
| Supplier | ARP |
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