| Product Name | Anti-Sca1 / Ly6A/E Antibody [D7] |
|---|---|
| Description | Rat monoclonal [D7] antibody to Sca1 / Ly6A/E. |
| Host | Rat |
| Clonality | Monoclonal |
| Clone | D7 |
| Conjugate | Unconjugated |
| Immunogen | IL-2 dependent mouse T cell line CTL-L. |
| Isotype | IgG2a |
| Target | Sca1 / Ly6A/E |
| Specificity | This antibody recognises members of the lymphocyte activation protein-6 (Ly-6) multi-gene family. Specifically, it recognises Ly-6A.2 and Ly-6E.1. Ly-6A/E is also known as stem cell antigen-1 (Sca-1). It is an 18kDa mouse glycosyl phosphatidylinositol-anchored cell surface protein of the Ly-6 gene family. It is expressed on multipotent hematopoietic stem cells in bone marrow of mice with both the Ly-6.1 and Ly-6.2 allotypes. As such, it is the most common marker used for enriching adult hematopoietic stem cells. It has varied functions, it plays a role in bone formation, myoblast proliferation and differentiation and the activation and immunosuppressive function of T cells.Rat anti Mouse Ly-6A/E antibody, clone D7 has been reported to induce T cell activation. Removal of sodium azide is recommended prior to use in functional assays. |
| Reactivity | Mouse |
| Applications | IHC-Fr, FC, IP, WB |
| Form | Liquid |
| Diluent Buffer | Supplied in Borate Buffered Saline with <0.1% Sodium Azide. |
| Concentration | 500 µg/ml |
| Storage | Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. |
| Supplier | Antibodies.com |
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