| Product Name | Anti-sCD40 (soluble) Monoclonal Antibody |
|---|---|
| Description | CD40 is a 48 kD type I glycoprotein and a member of the TNFR superfamily primarily expressed on B cells, macrophages, follicular dendritic cells, endothelial cells, fibroblasts, and at low levels on plasma cells. CD40 is also expressed on a wide range of tumor cells, including non-Hodgkin's and Hodgkin's lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary.The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects. |
| Synonyms | CD40 Molecule, CD40L Receptor, TNFRSF5, CDW40, Bp50, Tumor Necrosis Factor Receptor Superfamily, Member, B Cell Surface Antigen CD40, CD40 Antigen, P50 |
| Host | Mouse |
| Clone | T8P2G4*A6 |
| Immunogen | Ovalbumin-conjugated synthetic peptide RDPVCHPLGA (C-terminal sequence) |
| Isotype | IgG1 kappa |
| Reactivity | Human |
| Applications | ELISA, IHC, WB |
| Background | CD40 is a 48 kD type I glycoprotein and a member of the TNFR superfamily primarily expressed on B cells, macrophages, follicular dendritic cells, endothelial cells, fibroblasts, and at low levels on plasma cells. CD40 is also expressed on a wide range of tumor cells, including non-Hodgkin's and Hodgkin's lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary.The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects. |
| Supplier | Vertebrate Antibodies Limited |
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