| Product Name | Anti-sCTLA4 Monoclonal Antibody |
|---|---|
| Description | CTLA4 (Cytotoxic T-Lymphocyte Antigen 4), also known as CD152, is a protein that plays an important regulatory role in the immune system. CTLA4 is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. Mutations in the CTLA4 gene have been associated with various autoimmune diseases, such as systemic lupus erythematosus, insulin-dependent diabetes mellitus, and other autoimmune diseases. A recently identified novel transcript of the CTLA-4 gene that may represent a native soluble form of CTLA-4 (sCTLA-4) showed that eleven of twenty patients with autoimmune thyroid disease (ATD ) had a high concentration of sCTLA-4, whereas only 1 of 30 apparently healthy volunteers contained measurable levels. sCTLA-4 immunoreactivity was inhibited by its binding to B7.1, suggesting that sCTLA-4 is a functional receptor. sCTLA4 also plays a role in the initial immune response to infection of immune cells by HIV, along with the CD-1 pathway and others. There is strong evidence showing variation of sCTLA4 levels between individuals ranging from approximately 150 to around 10,000 pg/ ml. One can speculate that those patients with high sCTLA4 levels are unlikely to benefit from CTLA4 therapy. Hence, it is crucial to measure/ quantify sCTLA4 before administering treatment. This anti-sCTLA4 antibody could prove a useful predictive biomarker. |
| Synonyms | Cytotoxic T-Lymphocyte Associated Protein 4, Insulin-Dependent Diabetes Mellitus 12, Celiac Disease 3, CTLA-4, CD152, CD152 Antigen, CELIAC3, IDDM12, ALPS5, GRD4, GSE, CD |
| Host | Mouse |
| Clone | L4P2F5*F10 |
| Immunogen | Ovalbumin-conjugated synthetic peptide CENAPNRARM |
| Isotype | IgG1 kappa |
| Reactivity | Bovine, Human, Mouse, Rat |
| Applications | ELISA, IHC, WB |
| Background |
CTLA4 (Cytotoxic T-Lymphocyte Antigen 4), also known as CD152, is a protein that plays an important regulatory role in the immune system. CTLA4 is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. Mutations in the CTLA4 gene have been associated with various autoimmune diseases, such as systemic lupus erythematosus, insulin-dependent diabetes mellitus, and other autoimmune diseases. A recently identified novel transcript of the CTLA-4 gene that may represent a native soluble form of CTLA-4 (sCTLA-4) showed that eleven of twenty patients with autoimmune thyroid disease (ATD ) had a high concentration of sCTLA-4, whereas only 1 of 30 apparently healthy volunteers contained measurable levels. sCTLA-4 immunoreactivity was inhibited by its binding to B7.1, suggesting that sCTLA-4 is a functional receptor. sCTLA4 also plays a role in the initial immune response to infection of immune cells by HIV, along with the CD-1 pathway and others. There is strong evidence showing variation of sCTLA4 levels between individuals ranging from approximately 150 to around 10,000 pg/ ml. One can speculate that those patients with high sCTLA4 levels are unlikely to benefit from CTLA4 therapy. Hence, it is crucial to measure/ quantify sCTLA4 before administering treatment. This anti-sCTLA4 antibody could prove a useful predictive biomarker. |
| Supplier | Vertebrate Antibodies Limited |
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