| Product Name | Anti-Single Chain Urokinase Monoclonal Antibody |
|---|---|
| Description | This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Mouse monoclonal Antibody toSingle Chain Urokinase. |
| Synonyms | ATF, QPD, UPA, URK, u-PA, BDPLT5 |
| Clonality | Monoclonal |
| Clone | 35scu-PA |
| Immunogen | Recombinant human single-chain pro-urokinase |
| Isotype | IgG1,Kappa light chain |
| Specificity | The antibody binds to single-chain pro-urokinase, single chain urokinase, low molecular weight urokinase and also to two-chain urokinase-type plasminogen activator (uPA). |
| Reactivity | Human |
| Applications | ELISA, IHC, WB |
| Form | Affinity purified, 0.09 % sodium azide, 0.5% BSA in PBS buffer, pH 7.4, with Evans blue as counterstain |
| Storage | 2-8C for immediate use, or at -2°C (aliquot) |
| References | Plas, E. et al. (1998) Intl. J. Cancer 78 (3): 320-325 |
| Background | This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Supplier | ARP |
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