| Product Name | Anti-Sm BB' Proteins (Human autoantigens) Monoclonal Antibody |
|---|---|
| Description | The smith antigen was found to be a complex of ribonucleic acid (RNA) molecules and multiple proteins. A set of uridine-rich small nuclear RNA (snRNA) molecules was part of this complex, and given the names U1, U2, U4, U5 and U6. Four of these snRNAs (U1, U2, U4 and U5) were found to be tightly bound to several small proteins, which were named SmB, SmD, SmE, SmF, and SmG in decreasing order of size. SmB has an alternatively spliced variant, SmB', and a very similar protein, SmN replaces SmB'/B in certain (mostly neural) tissues. Mouse monoclonal antibody to Sm BB' proteins |
| Clonality | Monoclonal |
| Clone | ANA 125 |
| Immunogen | Spleen cells from an MRL/lpr mouse |
| Isotype | IgG2a |
| Specificity | The Mab reacts with the Sm BB' proteins, contained in major snRNPs (U1, U2, U4/U6 and U5 snRNPs). |
| Reactivity | Human |
| Applications | IF, IP, WB |
| Form | Hybridoma culture Supernatant |
| Storage | 2-8C |
| References | Manual of Biological Markers of Disease (1993) Section A (Eds. W.J. van Venrooij & R.N. Maini), Kluwer Acad. Publ. Dordrecht |
| Background | The smith antigen was found to be a complex of ribonucleic acid (RNA) molecules and multiple proteins. A set of uridine-rich small nuclear RNA (snRNA) molecules was part of this complex, and given the names U1, U2, U4, U5 and U6. Four of these snRNAs (U1, U2, U4 and U5) were found to be tightly bound to several small proteins, which were named SmB, SmD, SmE, SmF, and SmG in decreasing order of size. SmB has an alternatively spliced variant, SmB', and a very similar protein, SmN replaces SmB'/B in certain (mostly neural) tissues. |
| Supplier | ARP |
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