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|Product Name||Anti-SMAC (clone AT19F2)|
|Description||SMAC/Diablo is one of the proapoptotic proteins. SMAC promotes caspase activation in the cytochrome c/Apaf-1/caspase-9 pathway by binding to inhibitor of apoptosis proteins (IAPs) and removing their inhibitory activity. In healthy cells, SMAC is a mitochondrial protein, but when cells undergo apoptosis, SMAC is released into the cytosol. SMAC is ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes|
|Applications||Dot blot, ELISA, WB|
|Clone||AT19F2. Anti-human SMAC mAb, clone AT19F2, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human SMAC/Diablo protein.|
|Form||Purified, in Phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol, 0.02% Sodium Azide.|
|Immunogen||Recombinant human SMAC/Diablo (56-239aa) purified from E. coli|
|References||McNeish. I.A., et al. (2003) Exp Cell Res 286(2): 186€“198Yu. J., et al. (2007) Oncogene 26(29): 4189€“4198 Vucic. D., et al. (2002) J Biol Chem 277(14): 12275€“12279|
|Storage||Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles.|
|Synonyms||SMAC3, DIABLO-S, FLJ10537, FLJ25049, Diablo isoform 1, SMAC/Diablo, Diablo isoform 1 0610041G12Rik, DBOH, Diablo homolog, DIABLO S, Diablo homolog (Drosophila), Mitochondrial Smac protein, Diablo homolog mitochondrial, SMAC 3, Smac protein, Direct IAP binding protein with low pI, Second mitochondria derived activator of caspase.|
|Working Dilutions||Optimal dilution should be performed by user.|
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