Anti-SMAC (clone AT19F2)

Antibodies, Monoclonal Antibodies
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Product Name Anti-SMAC (clone AT19F2)
Description SMAC/Diablo is one of the proapoptotic proteins. SMAC promotes caspase activation in the cytochrome c/Apaf-1/caspase-9 pathway by binding to inhibitor of apoptosis proteins (IAPs) and removing their inhibitory activity. In healthy cells, SMAC is a mitochondrial protein, but when cells undergo apoptosis, SMAC is released into the cytosol. SMAC is ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes
Reactivity Human
Applications Dot blot, ELISA, WB
Clone AT19F2. Anti-human SMAC mAb, clone AT19F2, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human SMAC/Diablo protein.
Concentration 0.1 mg/ml
Form Purified, in Phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol, 0.02% Sodium Azide.
Species Mouse
Host Mouse
Isotype K, IgG2a
Immunogen Recombinant human SMAC/Diablo (56-239aa) purified from E. coli
Interest Fields Cancer
NCBI Number NP_063940
References McNeish. I.A., et al. (2003) Exp Cell Res 286(2): 186€“198Yu. J., et al. (2007) Oncogene 26(29): 4189€“4198 Vucic. D., et al. (2002) J Biol Chem 277(14): 12275€“12279
Storage Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles.
Synonyms SMAC3, DIABLO-S, FLJ10537, FLJ25049, Diablo isoform 1, SMAC/Diablo, Diablo isoform 1 0610041G12Rik, DBOH, Diablo homolog, DIABLO S, Diablo homolog (Drosophila), Mitochondrial Smac protein, Diablo homolog mitochondrial, SMAC 3, Smac protein, Direct IAP binding protein with low pI, Second mitochondria derived activator of caspase.
Working Dilutions Optimal dilution should be performed by user.

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