| Product Name | Anti-Substance P Antibody [NC1/34] |
|---|---|
| Description | Rat monoclonal [NC1/34] antibody to Substance P. |
| Host | Rat |
| Clonality | Monoclonal |
| Clone | NC1/34 |
| Conjugate | Unconjugated |
| Immunogen | Substance P conjugated to Bovine Serum Albumin. |
| Isotype | IgG2a |
| Target | Substance P |
| Specificity | This antibody recognises the COOH terminal region of substance P, an eleven amino acid polypeptide neurotransmitter derived by proteolytic cleavage of protachykinin-1. Substance P binds to and activates the neurokinin-1 receptor. Substance P is a highly conserved neurotransmitter expressed throughout the animal kingdom. It is highly expressed in the spinal cord dorsal horn and dorsal root ganglia, but not in the ventral horn (Ribeiro-da-Silva andT Hökfelt 2000). It is also expressed in non-neuronal cells including microglia and other immune cells.Substance P has a role in several physiologic activities such as pain transmission, the vomiting reflex, salivary secretion and smooth muscle contraction (Hökfelt 2004). Rat anti substance P antibody, clone NC1/34 demonstrates ~5% reactivity with eledoisin a neurotransmitter identified in the octopus Genus Eledone. It does not react with Leu or Met-enkephalin, somatostatin or beta-endorphin in tested applications. |
| Reactivity | Amphibian, Other, Gallus, Aves, Camelus, Frog, Rodent, Crustacean, Bacteria, Bovine, Fish, Guinea Pig, Human, Insect, Porcine, Rabbit, Rat, Sheep, Zebrafish, Mammal |
| Applications | IHC-Fr, IF, IHC-P |
| Working Dilutions | IHC-Fr: 1:100 - 1:200, IHC-P: 1:100 - 1:200 |
| Form | Liquid |
| Diluent Buffer | Supplied in 0.05% Thiomersal. |
| Concentration | Lot Specific |
| Purity | Tissue Culture Supernatant |
| Storage | Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. |
| Supplier | Antibodies.com |
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