| Product Name | Anti-TCF4 / TF7L2 Polyclonall Antibody |
|---|---|
| Description | TCF4 (T cell factor 4; also known as TF7L2) serves as transcriptional activator affecting e.g. cell cycle and terminal cell differentiation. In the absence of Wnt signals, TCF4 interacts with TLE/Groucho corepressor, supressing the transcription of TCF4 target genes. Wnt signaling leads to stabilisation and accumulation of beta-catenin, which binds TCF4 N-terminus, whereas TCF4 C-terminal HMG-box domains interact with DNA. Cell death-associated Daxx protein or plakoglobin belong to negative regulators of TCF4-mediated transcription, on the other hand, there is a positive feedback loop of beta-catenin-TCF4 pathway comprising the p300 coactivator. |
| Clone | Polyclonal |
| Immunogen | Bacterially expressed full-length human TCF4 |
| Specificity | Tha polyclonal antibody reacts with TCF4. TCF4 (transcription factor 7-like 2; 66 kDa) serves as a transcriptional activator affecting e.g. cell cycle and terminal cell differentiation. |
| Reactivity | Human, Mouse |
| Applications | ICC, IHC, IP, WB |
| Form | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage | Store at 2-8°C. Do not freeze. |
| Background | TCF4 (T cell factor 4; also known as TF7L2) serves as transcriptional activator affecting e.g. cell cycle and terminal cell differentiation. In the absence of Wnt signals, TCF4 interacts with TLE/Groucho corepressor, supressing the transcription of TCF4 target genes. Wnt signaling leads to stabilisation and accumulation of beta-catenin, which binds TCF4 N-terminus, whereas TCF4 C-terminal HMG-box domains interact with DNA. Cell death-associated Daxx protein or plakoglobin belong to negative regulators of TCF4-mediated transcription, on the other hand, there is a positive feedback loop of beta-catenin-TCF4 pathway comprising the p300 coactivator. |
| Supplier | Exbio |
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