| Product Name | Anti-TCP1 epsilon / CCT5 Antibody [PK/29/23/8d] |
|---|---|
| Description | Rat monoclonal [PK/29/23/8d] antibody to TCP1 epsilon / CCT5. |
| Host | Rat |
| Clonality | Monoclonal |
| Clone | PK/29/23/8d |
| Conjugate | Unconjugated |
| Isotype | IgG2a |
| Molecular Weight | Approximately 60 kDa in lysates of heat shocked Hela cells. |
| Target | TCP1 epsilon / CCT5 |
| Specificity | This antibody recognises the epsilon polypeptide of the CCT chaperonin molecule complex. CCT epsilon, also known as T-complex protein 1 subunit epsilon, CCT5 or CCTe is a 540 amino acid ~60 kDa molecular chaperone. The intact CCT complex is composed of eight polypeptides in a double-ring structure. CCT is important within cells in aiding the folding of proteins including actin, tubulin and the VHL tumour suppressor protein.Two isoforms of CCTe produced by alternative splicing have been described. Rat anti CCT epsilon antibody, clone PK/29/23/8d binds to the canonical isoform 1, binding to the truncated isoform 2 has not been evaluated (UniProt : P48643).Mutations in the CCT5 gene can lead to the development of Neuropathy, hereditary sensory, with spastic paraplegia, autosomal recessive (HSNSP) a disease characterized by spastic paraplegia and progressive neuropathy with limb ulceration. |
| Reactivity | Bovine, Human, Mouse, Rabbit, Rat |
| Applications | Gel Supershift Assays, IP, WB |
| Working Dilutions | WB: 1:250 - 1:500 |
| Form | Liquid |
| Diluent Buffer | Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide. |
| Concentration | 1 mg/ml |
| Storage | Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. |
| Supplier | Antibodies.com |
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