| Product Name | Anti-Tenascin Monoclonal Antibody |
|---|---|
| Description | This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. Tenascin is a large hexamic extracellular matrix molecule with oncofetal properties. During embryonic development the protein is expressed in many parenchymatous organs, where it appears to have a regulating role in epithelial differentiation. In most mature tissues the expression is restricted to the papillry dermis, but reappears in tissue regeneration and repair and in neoplasia. In basal cell carcinoma tow forms (Mr 210.000 & 300,000 kDa) of tenascin can be found, in contrast to normal skin and fibroblasts, where one form predominantly exists (Mr 300,000 kDa). |
| Synonyms | GP, JI, TN, HXB, GMEM, TN-C, 150-225 |
| Clonality | Monoclonal |
| Clone | T2H5 |
| Immunogen | Isolated from human mammary tumor |
| Isotype | IgG1 |
| Specificity | Detects extracellular matrix glycoprotein Tenascin in connection with gliomas, mammary tumors and in proliferative skin diseases (psoriasis, skin tumors) |
| Reactivity | Human |
| Applications | IF, IHC, WB |
| Form | Hybridoma culture supernatant |
| Storage | 2-8C |
| References | Verstraeten, A.A., et al. (1992) British Journal of Dermatology 127 : 571-574Bosnan FT et al. (1992) Histochem. Cytochem. 24/4: 1-92Koukoulis GK et al. (1991) Human Pathol 22: 636-643 |
| Background | This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. |
| Supplier | ARP |
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