Anti-TIMP-3 (Tissue Inhibitor of Metalloproteinase-3), Monoclonal Antibody
| Product Name | Anti-TIMP-3 (Tissue Inhibitor of Metalloproteinase-3), Monoclonal Antibody |
|---|---|
| Description | TIMP3 (tissue inhibitor of metalloproteinases 3), along with family members TIMP1, TIMP2, and TIMP4, are inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix (ECM). An imbalance between MMPs and the associated TIMPs may play a significant role in the invasive phenotype of malignant tumors. TIMP s inhibit the proteolytic invasiveness of tumor cells and normal placental trophoblast cells. TIMP-3 may be involved in regulating trophoblastic invasion of the uterus as well as in regulating remodeling of the extracellular matrix during the folding of epithelia, and in the formation, branching and expansion of epithelial tubes. |
| Synonyms | HSMRK222, K222TA2, Protein MIG-5, SFD, Sorsby fundus dystrophy pseudo-inflammatory, TIMP metallopeptidase inhibitor 3, Tissue Inhibitor of Metalloproteinase 3 |
| Host | Rabbit |
| Clonality | Monoclonal |
| Immunogen | The amino acid sequence (aa175-211), used as the immunogen for TIMP3 Ab, is 100% homologous in human, cow, dog and horse, and 94% homologous in mouse and rat. |
| Isotype | IgG |
| Reactivity | Bovine, Canine, Equine, Human, Mouse, Rat |
| Applications | FC, IF, IHC |
| Form | 200ug/ml of Ab purified from rabbit anti-serum by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml. |
| Gene Id | 7078 |
| Uniprot | P35625 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Nagase, H. et al. (2006) Cardiovasc Res 69, 562-73.Visse, R. and Nagase, H. (2003) Circ Res 92, 827-39. |
| Supplier | ARP |
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