Anti-Topoisomerase (DNA) I, Mitochondrial (TOP1MT), Monoclonal Antibody
| Product Name | Anti-Topoisomerase (DNA) I, Mitochondrial (TOP1MT), Monoclonal Antibody |
|---|---|
| Description | DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Due to their roles in DNA replication, recombination, and transcription, DNA topoisomerases have been identified as targets of numerous anticancer drugs. Mitochondrial Topo I (DNA topoisomerase I, mitochondrial) is a 601 amino acid protein that primarily acts to relieve DNA strain that may occur during duplication of mitochondrial DNA. As a type IB topoisomerase, mitochondrial Topo I requires a divalent metal, either, calcium or magnesium, as well as an alkaline pH for optimal activity. |
| Synonyms | DNA topoisomerase I, TOP1MT, Topoisomerase I mitochondrial, Type IB Topoisomerase |
| Host | Mouse |
| Clone | TOP1MT/488 |
| Immunogen | Recombinant full-length human TOP1MT protein |
| Isotype | IgG2b, kappa |
| Reactivity | Human |
| Applications | FC, IF, IHC |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Gene Id | 116447 |
| Uniprot | Q969P6 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References |
Zhang, H., Barcela, J.M., Lee, B., Kohlhagen, G., Zimonjic, D.B., Popescu, N.C. and Pommier, Y. 2001. Human mitochondrial topoisomerase I. Proc. Natl. Acad. Sci. USA 98: 10608-10613. Zhang, H., Meng, L.H. and Pommier, Y. 2007. Mitochondrial topoisomerases and alternative splicing of the human TOP1mt gene. Biochimie 89: 474-481 |
| Supplier | ARP |
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