| Product Name | Anti-Transferrin Receptor (CD 71) Monoclonal Antibody |
|---|---|
| Description | Transferrin receptor (TfR) is a carrier protein for transferrin. It is needed for the import of iron into the cell and is regulated in response to intracellular iron concentration. It imports iron by internalizing the transferrin-iron complex through receptor-mediated endocytosis. Mab PAL-M1 can be used to discriminate between malignant cutaneous melanoma and nevocellular nevi. |
| Synonyms | T9, TR, TFR, p90, CD71, TFR1, TRFR |
| Clonality | Monoclonal |
| Clone | PAL-M1 |
| Immunogen | Transferrin receptor isolated from human melanoma cells |
| Isotype | IgG1 |
| Specificity | It recognizes the tranferrin receptor (TFR, CD 71), a marker for tumor progression in the melanocytic lineage and stains the majority of primary melanomas and their metastases. |
| Reactivity | Human, Mouse |
| Applications | IHC, WB |
| Form | Hybridoma culture supernatant |
| Storage | 2-8C |
| References | Ruiter, D.J. et al.(1985) J. of Invest. Dermatology, 85: 4-8Van Muijen, G.N.P. et al. (1990) J. of Invest. Dermatology 1: 65-69 |
| Background | Transferrin receptor (TfR) is a carrier protein for transferrin. It is needed for the import of iron into the cell and is regulated in response to intracellular iron concentration. It imports iron by internalizing the transferrin-iron complex through receptor-mediated endocytosis |
| Supplier | ARP |
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