| Product Name | Anti-Transferrin Receptor Antibody [8D3] (FITC) |
|---|---|
| Description | Rat monoclonal [8D3] antibody to Transferrin Receptor (FITC). |
| Host | Rat |
| Clonality | Monoclonal |
| Clone | 8D3 |
| Conjugate | FITC |
| Immunogen | Mouse transformed endothelioma cell line (tEnd.1). |
| Isotype | IgG2a |
| Target | Transferrin Receptor |
| Specificity | This antibody recognises mouse CD71, a 763 amino acid ~95 kDa single pass type II cell surface transmembrane glycoprotein, otherwise known as the transferrin receptor. CD71 is a major iron-binding protein, which plays a key role in the transport of iron into cells that require it. In mice, CD71 is widely expressed on a variety of cells, including Sertoli cells and cells which form the blood brain barrier (BBB) in the central nervous system.recognises native, soluble and denatured forms of murine CD71. Binding of the 8D3 antibody to CD71 does not inhibit the proliferation of cell lines tested, and does not interfere with the uptake of iron into cells.Rat anti Mouse CD71 antibody, clone 8D3 has been used as a BBB transporter vector in mice and is suitable for studying CD71 expression, and iron uptake into different tissues, in the mouse. |
| Reactivity | Mouse |
| Applications | FC |
| Working Dilutions | Flow Cytometry: Neat, Use 10µl of the suggested working dilution to label 106 |
| Form | Liquid |
| Diluent Buffer | Supplied in Phosphate Buffered Saline with 1% BSA and 0.09% Sodium Azide. |
| Concentration | 100 µg/ml |
| Storage | Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. This product is photosensitive and should be protected from light. |
| Supplier | Antibodies.com |
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