| Product Name | Anti-Tropomodulin 1 Antibody [TRM-17 (Mab17)] |
|---|---|
| Description | Mouse monoclonal [TRM-17 (Mab17)] antibody to Tropomodulin 1. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | TRM-17 (Mab17) |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Chicken tropomodulin 1. |
| Isotype | IgG1 |
| Molecular Weight | Approximately 40 kDa in chick heart lysates. |
| Target | Tropomodulin 1 |
| Specificity | This antibody recognises chicken tropomodulin 1, otherwise known as erythrocyte tropomodulin or E-Tmod, an evolutionary very highly conserved cytoskeletal protein. Tropomodulin 1 is a sarcomeric protein highly expressed by erythrocytes, heart and skeletal muscle, which binds to and caps pointed ends of actin filaments to prevent thin filament elongation. The binding of the N-terminal region of Tmod1 with the actin-binding protein tropomyosin blocks the elongation and depolymerization of actin filaments, contributing to the geometry of the membrane skeleton.recognises an epitope between amino acid residues 6-57 within the N-terminal region of tropomodulin 1 and inhibits the binding of Tmod1 to tropomyosin. |
| Reactivity | Reptile, Gallus, Aves, Fish, Insect, Mammal |
| Applications | ELISA, FA, IF, WB |
| Form | Liquid |
| Diluent Buffer | Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide. |
| Concentration | 1 mg/ml |
| Storage | Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. |
| Supplier | Antibodies.com |
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