Anti-TTF-1 (Thyroid Transcription Factor-1) Monoclonal Antibody
| Product Name | Anti-TTF-1 (Thyroid Transcription Factor-1) Monoclonal Antibody |
|---|---|
| Description | This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TFF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription. The antibody is useful in the classification of thyroid and lung tumors |
| Synonyms | BCH, BHC, NK-2, TEBP, TTF1, NKX2A, TITF1, TTF-1, NKX2.1 |
| Clonality | Monoclonal |
| Clone | 8G7G3/1 |
| Immunogen | Rat TTF-1 Recombinant protein |
| Isotype | IgG1 |
| Specificity | The antibody recognizes a 40 kD protein, identified as thyroid transcription factor 1 (TTF-1), selectively expressed in the lung, thyroid and diencephalons. The antigen has been localized in the nucleus. |
| Reactivity | Human, Rat |
| Applications | ICC, IF, IHC |
| Form | Ascites containing 0.09% sodium azide |
| Storage | 2-8C for immediate use, or at -2°C (aliquot) |
| References | Holzinger, A.. et al.(1996) Hybridoma 15: 49-53 |
| Background | This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TFF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription. |
| Supplier | ARP |
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