| Product Name | Anti-Tubulin Monoclonal Antibody |
|---|---|
| Description | Tubulin is one of several members of a small family of globular proteins. The most common members of the tubulin family are alpha-tubulin and Beta-tubulin, the proteins that make up microtubules. Each has a molecular weight of approximately 55 kDa. Microtubules are assembled from dimers of alpha- and Beta-tubulin. These subunits are slightly acidic with an isoelectric point between 5.2 and 5.8. Tubulin was long thought to be specific to eukaryotes. Recently, however, the prokaryotic cell division protein FtsZ was shown to be evolutionarily related to tubulin. This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6. Tubulin is found in the microtubules which represents the main structural components of centriols, the mititic spindle, cilia and flagella |
| Synonyms | alphaTub, alphaTUB, beta-tub, beta-Tub |
| Clonality | Monoclonal |
| Clone | 655 |
| Immunogen | Tubulin isolated from chicken muscle |
| Isotype | IgM |
| Specificity | Tubulin. The antibody cross reacts with human tissue |
| Reactivity | Gallus, Human |
| Applications | ELISA, IF, IHC, WB |
| Form | Hybridoma culture supernatant |
| Storage | 2-8C |
| References | Blackstrom, B & Collins, VP. (1987) Neurotoxicology 1 (8): 85-96 |
| Background | Tubulin is one of several members of a small family of globular proteins. The most common members of the tubulin family are alpha-tubulin and Beta-tubulin, the proteins that make up microtubules. Each has a molecular weight of approximately 55 kDa. Microtubules are assembled from dimers of alpha- and Beta-tubulin. These subunits are slightly acidic with an isoelectric point between 5.2 and 5.8. Tubulin was long thought to be specific to eukaryotes. Recently, however, the prokaryotic cell division protein FtsZ was shown to be evolutionarily related to tubulin. This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6. |
| Supplier | ARP |
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