| Product Name | Anti-Uroplakin III Monoclonal Antibody |
|---|---|
| Description | This gene encodes a member of the uroplakin family, a group of transmembrane proteins that form complexes on the apical surface of the bladder epithelium. Mutations in this gene may be associated with renal adysplasia. Alternatively spliced transcript variants have been described. Mouse Monoclonal Antibody to Uroplakin III. Uroplakin is a membrane glycoprotein (47 kD) and has been shown to be a specific marker of terminal urothelial differentiation (Wu et al., 1993, 1994). |
| Synonyms | UP3A, UPK3, UPIII, UPIIIA |
| Clone | AU1 |
| Immunogen | Asymmetric unit membrane (AUM) preparation from bovine urinary bladder |
| Isotype | IgG1 |
| Specificity | Mab AU1 reacts specifically with uroplakin III present in the superficial cell layer of the urothelium. The binding region has been localized on the extracellular part of the antigen. Together with the uroplakins UP Ia, UP Ib and UP II, uroplakin III contributes in constituting the asym- metrical unit membrane of the plaques of urothelial superficial (um- brella) cells. |
| Reactivity | Bovine, Human, Porcine, Rat |
| Applications | WB |
| Form | Affinity purified, 0.09 % sodium azide, 0.5% BSA in PBS buffer, pH 7.4 |
| Storage | 2-8C for immediate use, or at -20C (aliquot) |
| References | Wu, XR & Sun TT (1993) J. Cell Sci. 106: 31-43Wu, XR et al. (1994) J. Biol. Chem. 269: 13716-13724 Moll R et al. (1995). Am. J. Pathol. 147: 1383-1397Romih R et al. (1998) Histochem. Cell Biol, 109: 263-269Kauffmann, O. et al. (2000) Am. J. Clin. Pathol. 113: 683-687Hu P et al. (2000) J. Cell Biol. 151: 961-971Riedel I et al. (2001) Virchows Arch. 438: 181-191Liang, F-X. et al. (2001) Biochem J. 355: 13-18 |
| Supplier | ARP |
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