Anti-ZAP70 (Chronic Lymphocytic Leukemia Marker), Monoclonal Antibody
| Product Name | Anti-ZAP70 (Chronic Lymphocytic Leukemia Marker), Monoclonal Antibody |
|---|---|
| Description | ZAP70 is a 70kDa protein tyrosine kinase found in T-cells and natural killer cells._Control of this protein translation is via the IgVH gene. ZAP70 protein is expressed in leukemic cells of approximately 25% of chronic lymphocytic leukemia (CLL) cases as well._Anti-ZAP70 expression is an excellent surrogate marker for the distinction between the Ig-mutated (anti-ZAP70 negative) and Ig-unmutated (anti-ZAP70 positive) CLL subtypes and can identify patient groups with divergent clinical courses. The anti-ZAP70 positive Ig-unmutated CLL cases have been shown to have a poorer prognosis. |
| Synonyms | Selective T cell defect, SRK, STD, Syk-related tyrosine kinase, Tyrosine-protein kinase ZAP-70,TZK, Zeta chain associated protein kinase 70kDa |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | ZAP70/528 |
| Immunogen | Recombinant full-length human ZAP70 protein |
| Isotype | IgG2a, kappa |
| Reactivity | Human |
| Applications | FC, IF, IHC |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 1mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Gene Id | 7535 |
| Uniprot | P43403 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Iwashima M, Irving BA, van Oers NSC, Chan AC, Weiss A. Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases. Science 1994;263:1136-9 |
| Supplier | ARP |
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