| Product Name | APAF1 Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to APAF1 |
| Synonyms | APAF1-interacting protein; APIP; APIP2; CGI-29 protein; MMRP19 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Synthesized peptide derived from human APAF-1-ALT. |
| Isotype | IgG |
| Target | APAF1 |
| Reactivity | Human |
| Applications | ELISA, IF, IHC, WB |
| Form | liquid |
| Diluent Buffer | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Uniprot | O14727-6 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background |
This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. Keigo Machida, J. Biol. Chem., Apr 2001; 276: 12140 - 12146. Liam O __nnor, Cancer Res., Mar 2000; 60: 1217 - 1220. Zeping Wang, Nucleic Acids Res., Apr 2005; 33: 2248 - 2258 Govindaraj Anumanthan, Cancer Res., Nov 2006; 66: 10824 - 10832. |
| Supplier | Cusabio |
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