| Product Name | APBB1 Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to APBB1 |
| Synonyms | Adaptor protein FE65a2 antibody; Amyloid beta (A4) precursor protein binding family B member 1 antibody; Amyloid beta A4 precursor protein binding family B antibody; Amyloid beta A4 precursor protein binding family B member 1 antibody; Amyloid beta A4 precursor protein-binding family B member 1 antibody; Amyloid beta precursor protein binding family B member 1 antibody; APBB 1 antibody; APBB1 antibody; APBB1_HUMAN antibody; FE 65 antibody; Fe65 protein antibody; Protein Fe65 antibody; RIR antibody; stat like protein antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Recombinant human Amyloid beta A4 precursor protein-binding family B member 1 protein (361-710AA) |
| Isotype | IgG |
| Target | APBB1 |
| Reactivity | Human |
| Applications | ELISA, IHC |
| Form | Liquid |
| Diluent Buffer | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Uniprot | O00213 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background | Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its trancription activation activity. Function in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). |
| Supplier | Cusabio |
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