| Product Name | Apelin 12 |
|---|---|
| Description | Apelin 12 (A12) is a biologically active C-terminal fragment of the 77 amino acid prepropeptide apelin, which is also the precursor of apelin 13 and apelin 36. Apelin 12 lowers blood pressure via a nitric oxide-dependent mechanism and is involved in control of feeding through stimulation of cholecystokinin (CCK) secretion. Apelin 12 can also reduce infarct size (IS) and augment contractile function recovery in the heart of rodents after regional or global ischemia. |
| Synonyms | A12 |
| Molecular Weight | 1422.7 Da |
| Target | Apelin receptors |
| Amino Acid Sequence | RPRLSHKGPMPF |
| Form | Freeze dried solid |
| Purity | >95% by HPLC |
| Cas Number | 229961-08-4 |
| Storage | Store dessicated, frozen and in the dark |
| Notes | Modifications: None |
| References |
Tatemoto et al (1998) Isolation and Characterization of a Novel Endogenous Peptide Ligand for the Human APJ Receptor. Biochem. Biophys. Res. Commun. 251 (2) 471 PMID: 9792798Pisarenko et al (2011) In vivo reduction of injury to the heart with apelin-12 peptide in rats. Bull. Exp. Biol. Med. 152(1) 79 PMID: 22803046Pisarenko et al (2013) Effects of structural analogues of apelin-12 in acute myocardial infarction in rats. J. Pharmacol. Pharmacother. 4(3) 198 PMID: 23960425 Related areasAll peptides >All apelin receptor modulators >All cardiovascular research categories >All appetite regulation research categories >All neuroscience research categories > |
| Supplier | Isca Biochemicals Limited |
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