| Product Name | APL1_28, Human, ELISA Kit |
|---|---|
| Description | APLP1 and APLP2 (bAPP like protein 1, 2) are known to have similar primary structures to APP (Amyloid precursor protein). In recent years, it has been reported that three length types of APLP1-derived Ab (Amyloidb)-like peptides, APL1b25, APL1b27 and APL1b28 that are generated by BACE (b-secretase) and y-secretase are present in CSF (cerebrospinal fluid). (ref. 1) The report also indicates that these APL1b peptides are secreted via similar processes to Ab but they were not deposited in AD (Alzheimer disease) brain. Additionally, in some experiments using cultured cells, relative production of APL1b28 was regulated as well as that of Ab42, and the usability of measuring of APL1b28 in CSF is suggested as a candidate surrogate marker for the Ab42 in brain. Thus, APL1b peptides are expected to be novel biomarkers of AD research. This product can measure human APL1b28. This kit is a solid phase sandwich ELISA using 2 kinds of highly specific antibodies. Tetra Methyl Benzidine (TMB) is used as a coloring agent (Chromogen). The strength of coloring is proportional to the quantities of Human APL1b28. |
| Reactivity | Human |
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